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The association between LIN28A gene rare variants and Parkinson's disease in Chinese population.

Gene - 30 Jun 2022

Huang Xiurong, Zhao Yuwen, Pan Hongxu, Wang Yige, Liu Zhenhua, Xu Qian, Sun Qiying, Tan Jieqiong, Yan Xinxiang, Li Jinchen, Tang Beisha, Guo Jifeng

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disease caused by aging, environmental and genetic factors, and many susceptibility genes have been found to increase the risk for PD. Lin28a, an RNA binding protein, is expressed prominently in neural progenitor cells. The expression of Lin28a is decreased gradually with neural differentiation and is implicated in oncogenesis, glucose metabolism, neurogenesis, and...

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PMID: 35447238
DOI: 10.1016/j.gene.2022.146515

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