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Analysis of LIN28A variants in patients with Parkinson's disease.

Journal of human genetics - 1 May 2023

Peng Hao, Li Yuanzhe, Yoshino Hiroyo, Shimizu Mai, Nishioka Kenya, Funayama Manabu, Hattori Nobutaka

Abstract excerpt

A heterozygous loss-of-function variant in lin-28 homolog A (LIN28A) was recently reported as a novel pathogenic gene in patients with PD from Korea. Two patients harboring LIN28A variants had early- or middle-aged-onset PD with good responses to levodopa. In the current study, we aimed to identify the prevalence of LIN28A variants among PD patients of Japanese origin. We performed genetic sequencing of 284...

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PMID: 36658347
DOI: 10.1038/s10038-022-01109-x

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