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Article

Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis.

Journal of leukocyte biology - 1 Mar 2014

Chandra Rachna, Federici Stephanie, Németh Zoltán H, Csóka Balázs, Thomas James A, Donnelly Robert, Spolarics Zoltán

Abstract excerpt

ChrX cellular mosaicism for X-linked genetic polymorphisms in females versus the single ChrX representation in males denotes a genetic difference, which may contribute to gender bias in the inflammatory response. This hypothesis was tested in female F1 offspring of consomic mice (BL6J-ChrX(A/J)/NaJ) that were homokaryotic or mosaic for the active BL6 and AJ ChrXs or for IRAK1 deficiency linked to the BL6 ChrX....

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Share to Cell Separation
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Genes, X-Linked

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Share to Interleukin-1 Receptor-Associated Kinases

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Source

Open in PubMed Open full text

Identifiers

PMID: 24193737
DOI: 10.1189/jlb.0713397
PMCID: PMC3923084

Genes

IRAK1
BTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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