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Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression

9 Feb 2021

Abstract excerpt

Abstract Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphologically diverse tumor regions, termed histologic patterns. However, the link between molecular and histologic features remains elusive. Here, we generated multiomics and...

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PMID: 33563664
DOI: 10.1158/2159-8290.cd-20-1274

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