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Article

Stat3 mutations impact on overall survival in large granular lymphocyte leukemia: a single-center experience of 205 patients.

Leukemia - 1 Apr 2020

Barilà Gregorio, Teramo Antonella, Calabretto Giulia, Vicenzetto Cristina, Gasparini Vanessa Rebecca, Pavan Laura, Leoncin Matteo, Vedovato Susanna, Frigo Anna Chiara, Facco Monica, Semenzato Gianpietro, Zambello Renato

Abstract excerpt

Large granular lymphocyte leukemia (LGLL) is a rare and chronic lymphoproliferative disorder characterized by the clonal expansion of LGLs. LGLL patients can be asymptomatic or develop cytopenia, mostly neutropenia. Somatic STAT3 and STAT5b mutations have been recently reported in approximately 40% of patients. The aim of this study is to analyze clinical and biological features of a large cohort of LGLL patients...

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PMID: 31740810
DOI: 10.1038/s41375-019-0644-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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