Article
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.
Haematologica - 1 Jan 2015
Rajala Hanna L M, Olson Thomas, Clemente Michael J, Lagström Sonja, Ellonen Pekka, Lundan Tuija, Hamm David E, Zaman Syed Arshi Uz, Lopez Marti Jesus M, Andersson Emma I, Jerez Andres, Porkka Kimmo, Maciejewski Jaroslaw P, Loughran Thomas P, Mustjoki Satu
Abstract excerpt
T-cell large granular lymphocytic leukemia and chronic lymphoproliferative disorder of natural killer cells are intriguing entities between benign and malignant lymphoproliferation. The molecular pathogenesis has partly been uncovered by the recent discovery of somatic activating STAT3 and STAT5b mutations. Here we show that 43% (75/174) of patients with T-cell large granular lymphocytic leukemia and 18% (7/39)...
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