Article
Tγδ LGLL identifies a subset with more symptomatic disease: analysis of an international cohort of 137 patients.
Blood - 2 Mar 2023
Barilà Gregorio, Grassi Angela, Cheon HeeJin, Teramo Antonella, Calabretto Giulia, Chahal Jasmanet, Vicenzetto Cristina, Almeida Julia, Shemo Bryna C, Shi Min, Gasparini Vanessa Rebecca, Munoz-Garcia Noemi, Pastoret Cédric, Nakazawa Hideyuki, Oshimi Kazuo, Sokol Lubomir, Ishida Fumihiro, Lamy Thierry, Orfao Alberto, Morice William G, Loughran Thomas P, Semenzato Gianpietro, Zambello Renato
Abstract excerpt
Tγδ large granular lymphocyte leukemia (LGLL) is a rare variant of T-cell LGLL (T-LGLL) that has been less investigated as compared with the more frequent Tαβ LGLL, particularly in terms of frequency of STAT3 and STAT5b mutations. In this study, we characterized the clinical and biological features of 137 patients affected by Tγδ LGLL; data were retrospectively collected from 1997 to 2020 at 8 referral centers....
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