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Article

Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL).

Leukemia & lymphoma - 1 Feb 2018

Sanikommu Srinivasa R, Clemente Michael J, Chomczynski Peter, Afable Manuel G, Jerez Andres, Thota Swapna, Patel Bhumika, Hirsch Cassandra, Nazha Aziz, Desamito John, Lichtin Alan, Pohlman Brad, Sekeres Mikkael A, Radivoyevitch Tomas, Maciejewski Jaroslaw P

Abstract excerpt

Large granular lymphocytic leukemia (LGLL) represents a clonal/oligoclonal lymphoproliferation of cytotoxic T and natural killer cells often associated with STAT3 mutations. When symptomatic, due to mostly anemia and neutropenia, therapy choices are often empirically-based, because only few clinical trials and systematic studies have been performed. Incorporating new molecular and flow cytometry parameters, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28633612
DOI: 10.1080/10428194.2017.1339880
PMCID: PMC8694069

Genes

STAT3

Provenance

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