Article
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.
Blood - 30 May 2013
Rajala Hanna L M, Eldfors Samuli, Kuusanmäki Heikki, van Adrichem Arjan J, Olson Thomas, Lagström Sonja, Andersson Emma I, Jerez Andres, Clemente Michael J, Yan Yiyi, Zhang Dan, Awwad Andy, Ellonen Pekka, Kallioniemi Olli, Wennerberg Krister, Porkka Kimmo, Maciejewski Jaroslaw P, Loughran Thomas P, Heckman Caroline, Mustjoki Satu
Abstract excerpt
Large granular lymphocytic (LGL) leukemia is characterized by clonal expansion of cytotoxic T cells or natural killer cells. Recently, somatic mutations in the signal transducer and activator of transcription 3 (STAT3) gene were discovered in 28% to 40% of LGL leukemia patients. By exome and transcriptome sequencing of 2 STAT3 mutation-negative LGL leukemia patients, we identified a recurrent, somatic missense...
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