Article
Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
Cell death and differentiation - 1 May 2020
Kiss Viktória, Jipa András, Varga Kata, Takáts Szabolcs, Maruzs Tamás, Lőrincz Péter, Simon-Vecsei Zsófia, Szikora Szilárd, Földi István, Bajusz Csaba, Tóth Dávid, Vilmos Péter, Gáspár Imre, Ronchi Paolo, Mihály József, Juhász Gábor
Abstract excerpt
Autophagy ensures the turnover of cytoplasm and requires the coordinated action of Atg proteins, some of which also have moonlighting functions in higher eukaryotes. Here we show that the transmembrane protein Atg9 is required for female fertility, and its loss leads to defects in actin cytoskeleton organization in the ovary and enhances filopodia formation in neurons in Drosophila. Atg9 localizes to the plasma...
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