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Article

<i>Drosophila</i>Mitf regulates the V-ATPase and the lysosomal-autophagic pathway

13 Jan 2016

Abstract excerpt

An evolutionarily conserved gene network regulates the expression of genes involved in lysosome biogenesis, autophagy, and lipid metabolism. In mammals, TFEB and other members of the MiTF-TFE family of transcription factors control this network. Here we report that the lysosomal-autophagy pathway is controlled by Mitf gene in Drosophila melanogaster. Mitf is the single MiTF-TFE family member in Drosophila and...

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PMID: 26761346
DOI: 10.1080/15548627.2015.1134081

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