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Elucidating Molecular Design Principles for Charge-Alternating Peptides.

Biomacromolecules - 10 Feb 2020

Smith Josh, McMullen Patrick, Yuan Zhefan, Pfaendtner Jim, Jiang Shaoyi

Abstract excerpt

The therapeutic potential of protein drugs has been hindered by difficulties with long-term stability and rapid clearance from the body. Recombinant fusion proteins provide a scalable platform for engineered biologics, whereby a polypeptide domain is appended to alter the physical characteristics of a therapeutic protein and enhance its pharmaceutical viability. Two simple design principles for recombinant fusion...

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Identifiers

PMID: 31738521
DOI: 10.1021/acs.biomac.9b01191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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