Polymerized Short Sequences as a Template for Protein Folding and Evolution.

Abstract excerpt

Repeat proteins, known for their functional versatility and modularity, are focal points of de novo protein design. This study explores and discovers proteins with repeated sequences using evolutionary approaches. Leveraging AlphaFold 2, our initial sequence design integrates amyloid β42 with a random hexapeptide linker through polymerization, achieving high foldability in more than 12% of cases. We further...

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