Article
Design of a heterospecific, tetrameric, 21-residue miniprotein with mixed alpha/beta structure.
Structure (London, England : 1993) - 1 Feb 2005
Ali Mayssam H, Taylor Christina M, Grigoryan Gevorg, Allen Karen N, Imperiali Barbara, Keating Amy E
Abstract excerpt
The study of short, autonomously folding peptides, or "miniproteins," is important for advancing our understanding of protein stability and folding specificity. Although many examples of synthetic alpha-helical structures are known, relatively few mixed alpha/beta structures have been successfully designed. Only one mixed-secondary structure oligomer, an alpha/beta homotetramer, has been reported thus far. In...
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