Article
Increased expression of plasminogen activator inhibitor-1 (PAI-1) is associated with depression and depressive phenotype in C57Bl/6J mice.
Experimental brain research - 1 Dec 2019
Girard René A, Chauhan Prashant S, Tucker Torry A, Allen Tim, Kaur Jaswinder, Jeffers Ann, Koenig Kathleen, Florova Galina, Komissarov Andrey A, Gaidenko Tatiana A, Chamiso Mignote B, Fowler James, Morris Danna E, Sarva Krishna, Singh Karan P, Idell Steven, Idell Richard D
Abstract excerpt
Plasminogen activator inhibitor 1 (PAI-1), which is elevated in numerous disease states, has been implicated as a stress-related protein involved in the pathogenesis of depression. We measured PAI-1 in the plasma of healthy and depressed individuals and assessed plasminogen activator (PA) expression and regulation by PAI-1 in cultured normal human astrocytes (NHA). Elevated plasma PAI-1 levels were found in...
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