Article

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder

2024-08-19

Abstract excerpt

Anxiety disorders are accompanied by changes in brain plasticity, stress vulnerability and heightened risk of depression. Here, we found that serum LPA16:0 abundance increased with trait anxiety in both human and mice and was sufficient to reduce the proliferation of adult hippocampal neural stem/progenitor cells. In humans, the main LPA receptor, LPA 1 , bears single nucleotide polymorphism variants associated w...

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Literature Corpus work: 87f80a12-5f30-5bc3-86ba-9505dadd9893
DOI: 10.1101/2024.08.18.608479

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