Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia-an imaging genetics and independent replication approach.

doi:10.1093/scan/nsae054

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Article

Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia-an imaging genetics and independent replication approach.

Social cognitive and affective neuroscience - 19 Sept 2024

Leehr Elisabeth J, Brede Leonie S, Böhnlein Joscha, Roesmann Kati, Gathmann Bettina, Herrmann Martin J, Junghöfer Markus, Schwarzmeier Hanna, Seeger Fabian R, Siminski Niklas, Straube Thomas, Klahn Anna Luisa, Weber Heike, Schiele Miriam A, Domschke Katharina, Lueken Ulrike, Dannlowski Udo

Abstract excerpt

The functional neuropeptide S receptor 1 (NPSR1) gene A/T variant (rs324981) is associated with fear processing. We investigated the impact of NPSR1 genotype on fear processing and on symptom reduction following treatment in individuals with spider phobia. A replication approach was applied [discovery sample: Münster (MS) nMS = 104; replication sample Würzburg (WZ) nWZ = 81]. Participants were genotyped for NPSR1...

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PMID: 39167471
DOI: 10.1093/scan/nsae054
PMCID: PMC11412251

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