Article
Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.
PloS one - 1 Jan 2014
Tilstam Pathricia V, Gijbels Marion J, Habbeddine Mohamed, Cudejko Céline, Asare Yaw, Theelen Wendy, Zhou Baixue, Döring Yvonne, Drechsler Maik, Pawig Lukas, Simsekyilmaz Sakine, Koenen Rory R, de Winther Menno P J, Lawrence Toby, Bernhagen Jürgen, Zernecke Alma, Weber Christian, Noels Heidi
Abstract excerpt
BACKGROUND: The Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investigated the effect of a bone marrow (BM)-specific activation-resistant Ikkα mutant knock-in on haematopoiesis and atherosclerosis in mice....
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