Article
The role of allelic variation in estrogen receptor genes and major depression in the Nurses Health Study.
Social psychiatry and psychiatric epidemiology - 1 Dec 2015
Keyes K, Agnew-Blais J, Roberts A L, Hamilton A, De Vivo I, Ranu H, Koenen K
Abstract excerpt
PURPOSE: The role of exogenous and endogenous sex hormones in the etiology of depression remains elusive, in part because sex hormone variation is often correlated with behaviors, life stage changes, and other factors that may influence depression. Estrogen receptor alpha (ESR1) and beta (ESR2) are known to regulate gene expression and estrogen response in areas of the brain associated with major depression and...
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