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Article

Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720.

PloS one - 1 Jan 2019

Fukuda Aya, Honda Shiho, Fujioka Norie, Sekiguchi Yuya, Mizuno Seiya, Miwa Yoshihiro, Sugiyama Fumihiro, Hayashi Yohei, Nishimura Ken, Hisatake Koji

Abstract excerpt

Uncoupling protein 1 (UCP1) is a mitochondrial protein that is expressed in both brown and beige adipocytes. UCP1 uncouples the mitochondrial electron transport chain from ATP synthesis to produce heat via non-shivering thermogenesis. Due to their ability to dissipate energy as heat and ameliorate metabolic disorders, UCP1-expressing adipocytes are considered as a potential target for anti-obesity treatment. To...

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Identifiers

PMID: 31730675
DOI: 10.1371/journal.pone.0225213
PMCID: PMC6857924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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