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Article

Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model

8 Nov 2016

Abstract excerpt

Both mammals and adult humans possess classic brown adipocytes and beige adipocytes, and the amount and activity of these adipocytes are considered key factors in combating obesity and its associated metabolic diseases. Uncoupling protein 1 (Ucp1) is the functional marker of both brown and beige adipocytes. To facilitate a reliable, easy, and sensitive measurement of Ucp1 expression both in vivo and in vitro, we...

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PMID: 28108609
DOI: 10.2337/db16-0343

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