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Article

Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.

Molecular cell - 22 Jan 2015

Dempersmier Jon, Sambeat Audrey, Gulyaeva Olga, Paul Sarah M, Hudak Carolyn S S, Raposo Helena F, Kwan Hiu-Yee, Kang Chulho, Wong Roger H F, Sul Hei Sook

Abstract excerpt

Uncoupling protein 1 (UCP1) mediates nonshivering thermogenesis and, upon cold exposure, is induced in brown adipose tissue (BAT) and subcutaneous white adipose tissue (iWAT). Here, by high-throughput screening using the UCP1 promoter, we identify Zfp516 as a transcriptional activator of UCP1 as well as PGC1α, thereby promoting a BAT program. Zfp516 itself is induced by cold and sympathetic stimulation through...

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Share to Adipogenesis
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25578880
DOI: 10.1016/j.molcel.2014.12.005
PMCID: PMC4304950

Genes

UCP1
ATF2
PRDM16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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