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Germline competency of human embryonic stem cells depends on eomesodermin

30 Oct 2017

Abstract excerpt

In humans, germline competency and the specification of primordial germ cells (PGCs) are thought to occur in a restricted developmental window during early embryogenesis. Despite the importance of specifying the appropriate number of PGCs for human reproduction, the molecular mechanisms governing PGC formation remain largely unexplored. Here, we compared PGC-like cell (PGCLC) differentiation from 18 independently...

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PMID: 29091993
DOI: 10.1093/biolre/iox138

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