Unique genomic profile of fibrolamellar hepatocellular carcinoma.

doi:10.1053/j.gastro.2014.12.028

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Article

Unique genomic profile of fibrolamellar hepatocellular carcinoma.

Gastroenterology - 1 Apr 2015

Cornella Helena, Alsinet Clara, Sayols Sergi, Zhang Zhongyang, Hao Ke, Cabellos Laia, Hoshida Yujin, Villanueva Augusto, Thung Swan, Ward Stephen C, Rodriguez-Carunchio Leonardo, Vila-Casadesús Maria, Imbeaud Sandrine, Lachenmayer Anja, Quaglia Alberto, Nagorney David M, Minguez Beatriz, Carrilho Flair, Roberts Lewis R, Waxman Samuel, Mazzaferro Vincenzo, Schwartz Myron, Esteller Manel, Heaton Nigel D, Zucman-Rossi Jessica, Llovet Josep M

Abstract excerpt

BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors. METHODS: By using 78 clinically annotated FLC...

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Identifiers

PMID: 25557953
DOI: 10.1053/j.gastro.2014.12.028
PMCID: PMC4521774

Genes

DNAJB1
PRKACA
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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