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Article

Three ubiquitination sites of organic anion transporter-1 synergistically mediate protein kinase C-dependent endocytosis of the transporter.

Molecular pharmacology - 1 Jul 2013

Li Shanshan, Zhang Qiang, You Guofeng

Abstract excerpt

Organic anion transporter-1 (OAT1) mediates the body disposition of a diverse array of clinically important drugs, including anti-HIV therapeutics, antitumor drugs, antibiotics, antihypertensives, and anti-inflammatories. Therefore, understanding the regulation of OAT1 has profound clinical significance. We previously established that OAT1 constitutively internalizes from and recycles back to cell surface and...

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Identifiers

PMID: 23640180
DOI: 10.1124/mol.113.086769
PMCID: PMC3684823

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