Article
Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis.
Scientific reports - 14 Nov 2019
Saw Wuan-Geok, Wu Mu-Lu, Ragunathan Priya, Biuković Goran, Lau Aik-Meng, Shin Joon, Harikishore Amaravadhi, Cheung Chen-Yi, Hards Kiel, Sarathy Jickky Palmae, Bates Roderick W, Cook Gregory M, Dick Thomas, Grüber Gerhard
Abstract excerpt
The dynamic interaction of the N- and C-terminal domains of mycobacterial F-ATP synthase subunit ε is proposed to contribute to efficient coupling of H+-translocation and ATP synthesis. Here, we investigate crosstalk between both subunit ε domains by introducing chromosomal atpC missense mutations in the C-terminal helix 2 of ε predicted to disrupt inter domain and subunit ε-α crosstalk and therefore coupling....
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