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Article

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself.

Nature communications - 10 Aug 2016

Lamprecht Dirk A, Finin Peter M, Rahman Md Aejazur, Cumming Bridgette M, Russell Shannon L, Jonnala Surendranadha R, Adamson John H, Steyn Adrie J C

Abstract excerpt

The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the value of the ETC as a drug target, by measuring Mtb's respiration using extracellular flux...

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Identifiers

PMID: 27506290
DOI: 10.1038/ncomms12393
PMCID: PMC4987515

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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