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Article

Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection.

BMC systems biology - 21 Nov 2017

López-Agudelo Víctor A, Baena Andres, Ramirez-Malule Howard, Ochoa Silvia, Barrera Luis F, Ríos-Estepa Rigoberto

Abstract excerpt

BACKGROUND: Up to date, Mycobacterium tuberculosis (Mtb) remains as the worst intracellular killer pathogen. To establish infection, inside the granuloma, Mtb reprograms its metabolism to support both growth and survival, keeping a balance between catabolism, anabolism and energy supply. Mtb knockouts with the faculty of being essential on a wide range of nutritional conditions are deemed as target candidates for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29157227
DOI: 10.1186/s12918-017-0496-z
PMCID: PMC5697012

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GEM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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