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Article

Engineering rotor ring stoichiometries in the ATP synthase.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2012

Pogoryelov Denys, Klyszejko Adriana L, Krasnoselska Ganna O, Heller Eva-Maria, Leone Vanessa, Langer Julian D, Vonck Janet, Müller Daniel J, Faraldo-Gómez José D, Meier Thomas

Abstract excerpt

ATP synthase membrane rotors consist of a ring of c-subunits whose stoichiometry is constant for a given species but variable across different ones. We investigated the importance of c/c-subunit contacts by site-directed mutagenesis of a conserved stretch of glycines (GxGxGxGxG) in a bacterial c(11) ring. Structural and biochemical studies show a direct, specific influence on the c-subunit stoichiometry,...

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PMID: 22628564
DOI: 10.1073/pnas.1120027109
PMCID: PMC3382517

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