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Article

RNA degradation in antiviral immunity and autoimmunity

20 Feb 2015

Abstract excerpt

Post-transcriptional control determines the fate of cellular RNA molecules. Nonsense-mediated decay (NMD) provides quality control of mRNA, targeting faulty cellular transcripts for degradation by multiple nucleases including the RNA exosome. Recent findings have revealed a role for NMD in targeting viral RNA molecules, thereby restricting virus infection. Interestingly, NMD is also linked to immune responses at...

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PMID: 25709093
DOI: 10.1016/j.it.2015.02.001

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