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Article

HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells.

Nature communications - 31 May 2017

Kinner-Bibeau Lauren B, Sedlacek Abigail L, Messmer Michelle N, Watkins Simon C, Binder Robert J

Abstract excerpt

Immune responses primed by endogenous heat shock proteins, specifically gp96, can be varied, and mechanisms controlling these responses have not been defined. Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas high-dose immunization primes responses characterized by regulatory T (Treg) cells and immunosuppression. Here we show gp96 preferentially engages conventional and...

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Identifiers

PMID: 28561043
DOI: 10.1038/ncomms15648
PMCID: PMC5460028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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