Article
Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells.
Cell stress & chaperones - 1 Jul 2013
Spiering R, van der Zee R, Wagenaar J, van Eden W, Broere F
Abstract excerpt
Previously, it has been shown that heat shock protein 70 (HSP70) can prevent inflammatory damage in experimental autoimmune disease models. Various possible underlying working mechanisms have been proposed. One possibility is that HSP70 induces a tolerogenic phenotype in dendritic cells (DCs) as a result of the direct interaction of the antigen with the DC. Tolerogenic DCs can induce antigen-specific regulatory T...
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