Article
A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ tolerogenic dendritic cells.
Immunobiology - 1 Oct 2011
López Mercedes N, Pesce Bárbara, Kurte Mónica, Pérez Claudio, Segal Gabriela, Roa Johanna, Aguillón Juan Carlos, Mendoza-Naranjo Ariadna, Gesser Borbala, Larsen Christian, Villablanca Andrea, Choudhury Aniruddha, Kiessling Rolf, Salazar-Onfray Flavio
Abstract excerpt
We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery and increased sensitivity of tumor cells to NK-mediated lysis. In the present report, we have explored a potential therapeutic utility for IT9302 related to the ex vivo production of tolerogenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.