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Article

IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan.

Genes and immunity - 1 Jan 2007

Salih M A, Ibrahim M E, Blackwell J M, Miller E N, Khalil E A G, ElHassan A M, Musa A M, Mohamed H S

Abstract excerpt

Post-kala-azar dermal leishmanaisis (PKDL) in Sudan is associated with elevated interferon-gamma (IFN-gamma). To study interferon-gamma pathways in PKDL, we genotyped 80 trios from the Masalit ethnic group for polymorphisms at -470 ins/delTT, -270T/C, -56T/C and +95T/C in IFNGR1 and at -179G/A and +874T/A in IFNG. No associations occurred at IFNG. Global association with haplotypes comprising all four markers at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon gamma Receptor

Share to Leishmaniasis, Cutaneous

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 17136124
DOI: 10.1038/sj.gene.6364353
PMCID: PMC2330095

Genes

IFNGR1
IFNG

Provenance

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