Genetic associations of eosinophilic granulomatosis with polyangiitis in the Japanese population: exploring similarities and differences with European populations.

doi:10.1136/rmdopen-2025-006644

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Article

Genetic associations of eosinophilic granulomatosis with polyangiitis in the Japanese population: exploring similarities and differences with European populations.

RMD open - 9 Jul 2026

Kawasaki Aya, Ito-Naito Ikue, Sato Mina, Kawamura Yuka, Sada Ken-Ei, Itoh Kenji, Ono Nobuyuki, Hirano Fumio, Higuchi Tomoaki, Kobayashi Shigeto, Nagasaka Kenji, Sugihara Takahiko, Fujimoto Takashi, Kusaoi Makio, Kondo Yuya, Shimoyama Kumiko, Yamashita Keita, Higuchi Takashi, Kono Hajime, Ogawa Noriyoshi, Matsumoto Isao, Yamagata Kunihiro, Sumida Takayuki, Hashimoto Hiroshi, Makino Hirofumi, Arimura Yoshihiro, Harigai Masayoshi, Tamura Naoto, Tsuchiya Naoyuki

Abstract excerpt

OBJECTIVES: Eosinophilic granulomatosis with polyangiitis (EGPA) is classified as a subtype of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). A recent genome-wide association study (GWAS) of EGPA in populations of European ancestry reported several susceptibility loci. In view of population differences in genetic factors of AAV, we made an attempt to examine the contribution of these...

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PMID: 42431644
DOI: 10.1136/rmdopen-2025-006644
PMCID: PMC13358274

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MPO
TSLP
CDK6
IL5
LPP

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