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Article

The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence.

Cell death & disease - 15 Feb 2018

Ong Siew-Min, Hadadi Eva, Dang Truong-Minh, Yeap Wei-Hseun, Tan Crystal Tze-Ying, Ng Tze-Pin, Larbi Anis, Wong Siew-Cheng

Abstract excerpt

Human primary monocytes comprise a heterogeneous population that can be classified into three subsets based on CD14 and CD16 expression: classical (CD14high/CD16-), intermediate (CD14high/CD16+), and non-classical (CD14low/CD16+). The non-classical monocytes are the most pro-inflammatory in response to TLR stimulation in vitro, yet they express a remarkably high basal level of miR-146a, a microRNA known to...

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PMID: 29449647
DOI: 10.1038/s41419-018-0327-1
PMCID: PMC5833376

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