Article
Network control principles for identifying personalized driver genes in cancer.
Briefings in bioinformatics - 25 Sept 2020
Guo Wei-Feng, Zhang Shao-Wu, Zeng Tao, Akutsu Tatsuya, Chen Luonan
Abstract excerpt
To understand tumor heterogeneity in cancer, personalized driver genes (PDGs) need to be identified for unraveling the genotype-phenotype associations corresponding to particular patients. However, most of the existing driver-focus methods mainly pay attention on the cohort information rather than on individual information. Recent developing computational approaches based on network control principles are opening...
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