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Article

A novel network control model for identifying personalized driver genes in cancer.

PLoS computational biology - 1 Nov 2019

Guo Wei-Feng, Zhang Shao-Wu, Zeng Tao, Li Yan, Gao Jianxi, Chen Luonan

Abstract excerpt

Although existing computational models have identified many common driver genes, it remains challenging to identify the personalized driver genes by using samples of an individual patient. Recently, the methods of exploiting the structure-based control principles of complex networks provide new clues for identifying minimum number of driver nodes to drive the state transition of large-scale complex networks from...

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PMID: 31765387
DOI: 10.1371/journal.pcbi.1007520
PMCID: PMC6901264

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