Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.

doi:10.1038/s41562-023-01722-6

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Article

Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits.

Nature human behaviour - 1 Jan 2024

Ge Yi-Jun, Wu Bang-Sheng, Zhang Yi, Chen Shi-Dong, Zhang Ya-Ru, Kang Ju-Jiao, Deng Yue-Ting, Ou Ya-Nan, He Xiao-Yu, Zhao Yong-Li, Kuo Kevin, Ma Qing, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Gowland Penny, Heinz Andreas, Brühl Rüdiger, Martinot Jean-Luc, Martinot Marie-Laure Paillère, Artiges Eric, Nees Frauke, Orfanos Dimitri Papadopoulos, Lemaitre Herve, Paus Tomáš, Poustka Luise, Hohmann Sarah, Millenet Sabina, Fröhner Juliane H, Smolka Michael N, Vaidya Nilakshi, Walter Henrik, Whelan Robert, Feng Jian-Feng, Tan Lan, Dong Qiang, Schumann Gunter, Cheng Wei, Yu Jin-Tai

Abstract excerpt

The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with...

Topics

Humans
Child
Adolescent
Young Adult
Adult
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Aged, 80 and over

Alzheimer Disease

Genome-Wide Association Study

Phenotype

Cerebral Ventricles

Brain

Source

Open in PubMed

Identifiers

PMID: 37857874
DOI: 10.1038/s41562-023-01722-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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