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Article

Trajectories of brain aging in middle-aged and older adults: regional and individual differences.

NeuroImage - 1 Jun 2010

Raz Naftali, Ghisletta Paolo, Rodrigue Karen M, Kennedy Kristen M, Lindenberger Ulman

Abstract excerpt

The human brain changes with age. However, the rate and the trajectories of change vary among the brain regions and among individuals, and the reasons for these differences are unclear. In a sample of healthy middle-aged and older adults, we examined mean volume change and individual differences in the rate of change in 12 regional brain volumes over approximately 30 months. In addition to the baseline...

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Identifiers

PMID: 20298790
DOI: 10.1016/j.neuroimage.2010.03.020
PMCID: PMC2879584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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