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Genetic Predisposition to Alzheimer's Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region.

Genes - 27 May 2021

Ciampa Iacopo, Operto Grégory, Falcon Carles, Minguillon Carolina, Castro de Moura Manuel, Piñeyro David, Esteller Manel, Molinuevo Jose Luis, Guigó Roderic, Navarro Arcadi, Gispert Juan Domingo, Vilor-Tejedor Natalia, For The Alfa Study

Abstract excerpt

This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34072165
DOI: 10.3390/genes12060825
PMCID: PMC8226614

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