Article
Highly immunosuppressive HLADRhi regulatory T cells are associated with unfavorable outcomes in cervical squamous cell carcinoma.
International journal of cancer - 1 Apr 2020
Yang Huijuan, Ye Shuang, Goswami Shyamal, Li Teng, Wu Jingwen, Cao Chunmei, Ma Jiaqiang, Lu Bin, Pei Xuan, Chen Yanan, Yu Jing, Xu Huihui, Qiu Liwei, Afridi Saifullah, Xiang Libing, Zhang Xiaoming
Abstract excerpt
Regulatory T cells (Tregs) are crucial for the maintenance of peripheral tolerance, but they also limit beneficial responses through cancer-induced immunoediting. The roles of Treg subsets in cervical squamous cell carcinoma (CSCC) are currently unknown. Here, we aimed to perform an extensive study with an increased resolution of the Treg compartment in the peripheral blood and tumor tissues of CSCC patients. We...
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