Article
Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area.
Oncotarget - 20 Oct 2015
Heeren A Marijne, de Boer Eline, Bleeker Maaike C G, Musters René J P, Buist Marrije R, Kenter Gemma G, de Gruijl Tanja D, Jordanova Ekaterina S
Abstract excerpt
In cervical cancer, high frequencies of regulatory T cells (Tregs) and immunosuppressive PD-L1+CD14+ antigen-presenting cells dominate the microenvironment of tumor-positive lymph nodes (LN+). It is unknown whether this is restricted to LN+ or precedes metastasis, emanating from the primary tumor and spreading through tumor-draining lymph nodes (TDLNs). To investigate immunosuppression in the lymphatic basin of...
Topics
- Adult
- B7-H1 Antigen
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- Female
- Fluorescent Antibody Technique
- Forkhead Transcription Factors
- HLA-DR Antigens
- Humans
- Hysterectomy
- Immunophenotyping
- Lymph Node Excision
- Lymph Nodes