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Article

Induced regulatory T cells in inhibitory microenvironments created by cancer

17 Jun 2014

Abstract excerpt

INTRODUCTION: Regulatory T cells (Tregs) accumulating in the peripheral circulation and tumor sites of patients contribute to tumor escape from the host immune system. Tregs encompass subsets of immune cells with distinct phenotypic and functional properties. Whereas natural (n) or thymic-derived (t) Tregs regulate responses to self-antigens, inducible (i) or peripheral (p) Tregs generated and expanded in...

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PMID: 24934899
DOI: 10.1517/14712598.2014.927432

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