Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.

doi:10.1158/1078-0432.CCR-18-0554

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Article

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2018

Toker Aras, Nguyen Linh T, Stone Simone C, Yang S Y Cindy, Katz Sarah Rachel, Shaw Patricia A, Clarke Blaise A, Ghazarian Danny, Al-Habeeb Ayman, Easson Alexandra, Leong Wey L, McCready David R, Reedijk Michael, Guidos Cynthia J, Pugh Trevor J, Bernardini Marcus Q, Ohashi Pamela S

Abstract excerpt

Purpose: Regulatory T (Treg) cells expressing the transcription factor FOXP3 are essential for the maintenance of immunologic self-tolerance but play a detrimental role in most cancers due to their ability to suppress antitumor immunity. The phenotype of human circulating Treg cells has been extensively studied, but less is known about tumor-infiltrating Treg cells. We studied the phenotype and function of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30065096
DOI: 10.1158/1078-0432.CCR-18-0554

Genes

FOXP3
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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