Article
Beyond Canonical Immune Checkpoints: Overexpression of TNFRSF Members 4-1BB and OX-40 Marks T Cells Exhibiting Phenotypic Features of Exhaustion in Cervical Carcinoma.
Immunology - 1 Aug 2025
Rojas-Diaz Jose Manuel, Solorzano-Ibarra Fabiola, Garcia-Barrientos Nadia Tatiana, Klimov-Kravtchenko Ksenia, Cruz-Ramos Jose Alfonso, Guitron-Aviña Marcela Sofia, Urciaga-Gutierrez Pedro Ivan, Ortiz-Lazareno Pablo Cesar, Tellez-Bañuelos Martha Cecilia, Bueno-Topete Miriam Ruth, Haramati Jesse, Del Toro-Arreola Susana
Abstract excerpt
T cells are pivotal in combating cancer; however, they can become exhausted during tumour progression, losing their cytotoxic capacity and upregulating inhibitory receptors including PD-1 and TIGIT. While checkpoint blockade has emerged as a potent treatment option for numerous cancers, patient selection, long-term efficacy, and adverse effects still remain an issue. For these reasons, it is important to...
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