Article
The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.
Acta neuropathologica communications - 9 Nov 2019
Grandin Nathalie, Pereira Bruno, Cohen Camille, Billard Pauline, Dehais Caroline, Carpentier Catherine, Idbaih Ahmed, Bielle Franck, Ducray François, Figarella-Branger Dominique, Delattre Jean-Yves, Sanson Marc, Lomonte Patrick, Poncet Delphine, Verrelle Pierre, Charbonneau Michel
Abstract excerpt
All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomerase expression, the main pathway in most cancer types, or to activation of a mechanism called the alternative lengthening of telomeres (ALT). The presence of IDH1/2 mutations (IDH-mutant) together with loss...
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