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Article

Acquired ATRX Loss and ALT Phenotype Through Tumor Recurrences in a Case of Pleomorphic Xanthoastrocytoma Suggest Their Possible Roles in Tumor Progression.

Journal of neuropathology and experimental neurology - 1 Sept 2020

Dal Col Pierre, Poncet Delphine, Rivoirard Romain, Vassal François, Bernichon Emilie, Boutet Claire, Péoc'h Michel, Forest Fabien

Abstract excerpt

Pleomorphic xanthoastrocytoma (PXA) is classified as an astrocytic glioma occurring most often in children or young adults. Molecular alterations in PXA are not fully known, especially those associated with tumor progression. We describe a patient with several relapses of a PXA. The tumor showed an acquired ATRX loss through tumor evolution. We tested alternative lengthening of telomeres (ALT) with the C-circle...

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Identifiers

PMID: 32770176
DOI: 10.1093/jnen/nlaa074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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