Article
Involvement of c-Jun N-Terminal Kinase in TNF-α-Driven Remodeling.
American journal of respiratory cell and molecular biology - 1 Mar 2017
Eurlings Irene M J, Reynaert Niki L, van de Wetering Cheryl, Aesif Scott W, Mercken Evi M, de Cabo Rafael, van der Velden Jos L, Janssen-Heininger Yvonne M, Wouters Emiel F M, Dentener Mieke A
Abstract excerpt
Lung tissue remodeling in chronic obstructive pulmonary disease (COPD) is characterized by airway wall thickening and/or emphysema. Although the bronchial and alveolar compartments are functionally independent entities, we recently showed comparable alterations in matrix composition comprised of decreased elastin content and increased collagen and hyaluronan contents of alveolar and small airway walls. Out of...
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