Article
TGF-beta1 induces progressive pleural scarring and subpleural fibrosis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2007
Decologne Nathalie, Kolb Martin, Margetts Peter J, Menetrier Franck, Artur Yves, Garrido Carmen, Gauldie Jack, Camus Philippe, Bonniaud Philippe
Abstract excerpt
Pleural fibrosis is a misunderstood disorder which can cause severe restrictive lung disease with high morbidity and even mortality. The condition can develop in response to a large variety of diseases and tissue injury, among them infectious disease, asbestos, drugs, and radiation therapy. There is no efficient treatment to reverse established pleural fibrosis. TGF-beta1 is suspected, even if not proven, as a...
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